Beilstein J. Org. Chem.2022,18, 217–224, doi:10.3762/bjoc.18.25
226031, India Academy of Scientific and Innovative Research, Ghaziabad, 201002, India 10.3762/bjoc.18.25 Abstract A practical enantioselective N-selective nitrosoaldolreaction of α-methylmalonamates with a nitrosoarene is reported. The reaction employs the Takemoto thiourea catalyst for the induction
of enantioselectivity, and the corresponding optically active oxyaminated malonamates were obtained in reasonably good yields.
Keywords: enantioselective; malonamate; nitrosoaldolreaction; N-selectivity; Takemoto catalyst; Introduction
Nitrosoarenes are versatile building blocks frequently
noteworthy and widely explored transformations of nitrosoarenes include nitroso ene reactions [9][10][11], Diels–Alder cycloadditions [12][13][14][15][16][17][18], and nitroso aldol reactions [19][20][21][22][23]. Among the various applications of nitrosoarenes, the asymmetric nitrosoaldolreaction to